INNOVATION <br>WITHIN THE MEDICINE

INNOVATION
WITHIN THE MEDICINE

HOW CAN WE IMPROVE TODAYS WAY OF TREATMENT?

HUMAN MICROBIOME ENGINEERING

Microbiome as a key for treating
the untreatable
Over thousands of years of evolution, microbes were present in our bodies. Without them, a living organism could not survive because of lack of the immune system. In Passio Human Microbiome we are programming microorganisms to perform the desired task such as intensifying actions, dulling or even self-eliminating. Our research proves that those manipulations can provide a solid answer not only for gastrointestinal diseases but also asthma, autoimmune conditions, autism or even cancer. Passio Human Microbiome is a part of big change within the medicine.

THE HISTORY OF OUR RESEARCH

December 16′ – April 17′
MAPPING GUT MICROBIOME

During the past century, the noncommunicable diseases were the greatest reason for human deaths, even if we would compare it to infectious diseases. Trillions of commensal bacteria live in the human body and create as a whole the human microbiome. The great part of these microbes are located within the human gut (but not only) and have a significant impact on human health and survivor, including digesting food,  activation of a certain class of medicines, producing metabolites like short-chain fatty acids and anti-inflammatory substances, as well as stimulating the immune system.

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May 17′ – August 17′
THE EFFECT OF MICROBIOME ON A METABOLISM IN LIFESTYLE DISEASES

Interactions between microbiota and the host are very complex and play the crucial role not only in basic physiological processes but also in development (and healing!) of a number of chronic diseases: metabolic disorders like obesity and diabetes, gastrointestinal and cardiovascular diseases, mental disorders and even cancer, to name only a few. It is widely accepted now that human genotype and dietary habits aren’t the only factors contributing to the development of metabolic diseases. It is all about the interplay between these two and host microbiome composition. Obesity itself has been proven to be directly associated with gut microbiome dysbiosis resulting in damaged gut epithelial barrier and impaired metabolism overall.

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August 17′ – November 17′
THE ROLE OF GUT MICROBIOTA
IN RESPONSE TO A DRUG 

The oral administration of therapeutic drugs is an easy and preferred route over other administration routes, however, there are certain aspects that need special attention. Bioavailability of oral drugs primarily depends on well-functioning digestive system and microbiota that colonize the digestive system. It has been proved that human microbiome composition plays an important role in drug and xenobiotic metabolism by means of various enzymatic reactions mediated by microbiota produced enzymes.

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December 17′ – April 18′
IMPROVED ABSORPTION OF ACTIVE SUBSTANCE vs. IMPROVING THE EFFECTIVENESS OF PHARMACOTHERAPY

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. The primary goal of clinical pharmacokinetics includes enhancing efficiency and decreasing toxicity of a drug therapy.  

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THE EFFECT OF OUR WORK

THE EFFECT OF OUR WORK