Microbiome

Over 10 million people are living with IBD worldwide (over 3.4 million in Europe alone). It’s proven that the gut microbial unbalances are likely to contribute to disease severity. So that we are working on the solutions that will effectively balance the microbiome. Inflammatory Bowel Disease is a group of gastrointestinal inflammatory diseases which mainly comprises of Ulcerative colitis and Crohn’s disease. Inflammatory bowel diseases cause long terms chronic as well as severe inflammation in the gastrointestinal tract without any known cause.

Today the number of people with diabetes exceeded 422 million, it is forecasted that until 2035 this number will increase up to ½ billion. Globally, 10 times more people are living with diabetes than with HIV. Gut microbiota interacts with various host sensing and signalling pathways, leading to a modulation of the endocrine system, immune responses, nervous system activity, and hence, the predisposition to metabolic diseases. Gut microbiota dysbiosis drives and implies new therapeutic strategies for diabetes and related metabolic diseases. Based on that we are developing a new class of supportive treatment.

Although the microbial composition of the respiratory flora in COPD has been known through microbiome analyses, the involvement of the respiratory flora in the pathogenesis of the disease, and especially the role microorganisms considered non-pathogenic by culture-based microbiology, is practically unknown. We want to develop a treatment that will conserve the flora that acts as positive mutualist, as opposed to the respiratory pathogens that progressively replace it when COPD progresses to advanced disease.

Newest predictions said that 14 million people a year are diagnosed with cancer, but it is estimated that this number will increase to 19 million by 2025, 22 million by 2030 and 24 million by 2035. All scientific findings reveal alterations in the microbiota that may contribute to the aetiology of cancer. The extension of those findings may lead to strategies able to manipulate microbiota to support the treatment, prevent disease as well as to identify individuals at high risk.